Genome Scan for Locus Involved in Mandibular Prognathism in Pedigrees from China

Genome Scan for Locus Involved in Mandibular Prognathism in Pedigrees from China

BACKGROUND It is well known that genetic components play an important role in the etiology of mandibular prognathism, but few susceptibility loci have been mapped. METHODOLOGY In order to identify linkage regions for mandibular prognathism, we analyzed two Chinese pedigrees with 6,090 genome-wide single-nucleotide polymorphism (SNP) markers from Illumina Linkage-12 DNA Analysis Kit (average s...

Identification of a Mutation in FGF23 Involved in Mandibular Prognathism

Mandibular prognathism (MP) is a severe maxillofacial disorder with undetermined genetic background. We collected a Chinese pedigree with MP which involved in 23 living members of 4 generations. Genome-wide linkage analysis were carried out to obtain the information in this family and a new MP-susceptibility locus, 12pter-p12.3 was identified. Whole-exome sequencing identified a novel heterozyg...

Mandible in Mandibular Prognathism

Department of Orthodontics, School of Dentistry, National Taiwan University, Taipei; Department of Orthodontics, School of Dentistry, Kaohsiung Medical University, Kaohsiung; Institute of Biomechanical Engineering, National Cheng Kung University, Tainan. Received: 3 May 2002. Revised: 3 June 2002. Accepted: 9 July 2002. Reprint requests and correspondence to: Dr. Hong-Po Chang, Department of Or...

Genome scan of three quantitative traits in schizophrenia pedigrees.

BACKGROUND Twin and adoption studies have consistently implicated genes in the etiology of schizophrenia. Molecular genetic studies have found some consistent support for linkage to many regions of the genome. Despite these encouraging results, none of these findings have achieved genome-wide levels of statistical significance, and none have been consistently replicated. METHODS This report i...

Chin cup therapy for mandibular prognathism.